Revision means being willing to “see again,” to “start over” if necessary. If you’re committed to making a piece work, nothing can be sacred. You must be willing to let go of all of it.
When you achieve this mindset, question the largest issues such as the structure of the piece, its voice and protagonist. Make a list of several alternatives for every major element. For example, think of three or four distinctly different ways of structuring the piece. Think of several other characters who could be the protagonist. Think of a new way of stating your core point or theme.